◆MYC Gene Amplification Detection Probe

◆Product Advantages:  

1.Fleetness: Tissue probe hybridization time: 2 hours. Cell probe hybridization time: 1 hour. 

2.Accuracy: Less non-specific background staining (dyeing). Increase difficult samples detection rate. 

3.Reproducibility: Different laboratories test results are highly reproducible. 

◆About MYC gene

MYC proto-oncogene is located on chromosome 8q24 and encodes a transcription factor that regulates cell growth. It is mainly activated by amplification and chromosomal translocation rearrangement. MYC gene amplification is associated with the occurrence and development of a variety of tumors (including breast cancer, colon cancer, lung cancer, and hematopoietic tumors).

◆Probe Description

The MYC gene amplification probe uses orange-red dye to mark the MYC gene region, and the green dye to mark the centromeric region of chromosome 8 (CEP8). The MYC gene tagged region is located at 8q24.21 and the CEP8 probe is labeled with a specific alpha satellite sequence.

◆Clinical Significance

MYC gene amplification is a common phenomenon in tumors and can be seen in many malignant tumors such as breast cancer, nasopharyngeal cancer, and cervical cancer. The prognosis of breast cancer patients with MYC gene is poor.

◆Size Specifications

◆References

Fromont G, et al. (2013) Hum Pathol 44: 1617-23.

Mannuci S, et al. (2012) Adv Hematol 2012: 149780.

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